CEST imaging of fast exchanging amine pools with corrections for competing effects at 9.4 T.

ABSTRACT: Chemical exchange saturation transfer (CEST) imaging of fast exchanging amine protons at 3 ppm offset from the water resonant frequency is of practical interest, but quantification of fast exchanging pools by CEST is challenging. To effectively saturate fast exchanging protons, high irradiation powers need to be applied, but these may cause significant direct water saturation as well as non-specific semi-solid magnetization transfer (MT) effects, and thus decrease the specificity of the measured signal. In addition, the CEST signal may depend on the water longitudinal relaxation time (T_1w ), which likely varies between tissues and with pathology, further reducing specificity. Previously, an analysis of the asymmetry of saturation effects (MTR_asym ) has been commonly u

SUBMITTER: Zhang XY 

PROVIDER: S-EPMC5490838 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature