Comparative sequencing provides insights about the structure and conservation of marsupial and monotreme genomes.

ABSTRACT: Sequencing and comparative analyses of genomes from multiple vertebrates are providing insights about the genetic basis for biological diversity. To date, these efforts largely have focused on eutherian mammals, chicken, and fish. In this article, we describe the generation and study of genomic sequences from noneutherian mammals, a group of species occupying unusual phylogenetic positions. A large sequence data set (totaling >5 Mb) was generated for the same orthologous region in three marsupial (North American opossum, South American opossum, and Australian tammar wallaby) and one monotreme (platypus) genomes. These ancient mammalian genomes are characterized by unusual architectural features with respect to G + C and repeat content, as well as compression relative to human. Approximatel

SUBMITTER: Margulies EH 

PROVIDER: S-EPMC549084 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature