Biomarker Guided Therapy in Chronic Heart Failure.

ABSTRACT: This review article addresses the question of whether biomarker-guided therapy is ready for clinical implementation in chronic heart failure. The most well-known biomarkers in heart failure are natriuretic peptides, namely B-type natriuretic peptide (BNP) and N-terminal pro-BNP. They are well-established in the diagnostic process of acute heart failure and prediction of disease prognosis. They may also be helpful in screening patients at risk of developing heart failure. Although studied by 11 small- to medium-scale trials resulting in several positive meta-analyses, it is less well-established whether natriuretic peptides are also helpful for guiding chronic heart failure therapy. This uncertainty is expressed by differences in European and American guideline recommendations. In addition

SUBMITTER: Brunner-La Rocca HP 

PROVIDER: S-EPMC5490943 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature