RNA m⁶A methylation regulates the ultraviolet-induced DNA damage response.

ABSTRACT: Cell proliferation and survival require the faithful maintenance and propagation of genetic information, which are threatened by the ubiquitous sources of DNA damage present intracellularly and in the external environment. A system of DNA repair, called the DNA damage response, detects and repairs damaged DNA and prevents cell division until the repair is complete. Here we report that methylation at the 6 position of adenosine (m⁶A) in RNA is rapidly (within 2 min) and transiently induced at DNA damage sites in response to ultraviolet irradiation. This modification occurs on numerous poly(A)⁺ transcripts and is regulated by the methyltransferase METTL3 (methyltransferase-like 3) and the demethylase FTO (fat mass and obesity-associated protein). In the absence of METTL

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC5490984 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature