Genetic association of FTO/IRX region with obesity and overweight in the Polish population.

ABSTRACT:

Background/objectives

Genome-wide association studies (GWAS) have identified many loci associated with body mass index (BMI) in many different populations. Variants in the FTO locus are reported to be one of the strongest genetic predictors of obesity. Recent publications pointed also to a topologically associated domain (TAD) which is identified as a novel region affecting BMI. The TAD area encompasses the IRXB cluster (IRX3, IRX5, IRX6), FTO and RPGRIP1L genes.

Subjects/methods

In this study, we investigated the relationship between variation of the FTO and IRX genes and obesity in Poles. We presented a case-control association analysis (normal versus overweight and/or obesity group) of Polish adult individuals (N = 5418). We determined whether or not the chromosomal regio

SUBMITTER: Sobalska-Kwapis M 

PROVIDER: S-EPMC5491248 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature