Galactosylation of IgA1 Is Associated with Common Variation in <i>C1GALT1</i>.

ABSTRACT: IgA nephropathy (IgAN), an important cause of kidney failure, is characterized by glomerular IgA deposition and is associated with changes in O-glycosylation of the IgA1 molecule. Here, we sought to identify genetic factors contributing to levels of galactose-deficient IgA1 (Gd-IgA1) in white and Chinese populations. Gd-IgA1 levels were elevated in IgAN patients compared with ethnically matched healthy subjects and correlated with evidence of disease progression. White patients with IgAN exhibited significantly higher Gd-IgA1 levels than did Chinese patients. Among individuals without IgAN, Gd-IgA1 levels did not correlate with kidney function. Gd-IgA1 level heritability (h²), estimated by comparing midparental and offspring Gd-IgA1 levels, was 0.39. Genome-wide associati

SUBMITTER: Gale DP 

PROVIDER: S-EPMC5491291 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature