A Quantitative Comparison of Antibodies to Programmed Cell Death 1 Ligand 1.

ABSTRACT:

Importance

Assessment of PD-L1 (programmed cell death 1 ligand 1) expression by immunohistochemical analysis has been used as a predictive diagnostic test to identify responders and guide treatment in trials of the PD-1 (programmed cell death 1) axis inhibitors. The definition of PD-L1 positive lacks standardization, and prediction of response by immunohistochemical analysis is additionally limited by the subjective nature of this technique.

Objective

To examine whether PD-L1 antibody reagents are interchangeable by quantitatively comparing the expression of the PD-L1 protein.

Design, setting, and participants

In this immunohistochemistry standardization study, 30 randomly selected cases of lung cancer resected from January 1, 2008, through December 31, 2009, were obt

SUBMITTER: Gaule P 

PROVIDER: S-EPMC5491359 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature