Does time heal all wounds? Experimental diffuse traumatic brain injury results in persisting histopathology in the thalamus.

ABSTRACT:

Background

Thalamic dysfunction has been implicated in overall chronic neurological dysfunction after traumatic brain injury (TBI), however little is known about the underlying histopathology. In experimental diffuse TBI (dTBI), we hypothesize that persisting histopathological changes in the ventral posteromedial (VPM) nucleus of the thalamus is indicative of progressive circuit reorganization. Since circuit reorganization in the VPM impacts the whisker sensory system, the histopathology could explain the development of hypersensitivity to whisker stimulation by 28days post-injury; similar to light and sound hypersensitivity in human TBI survivors.

Methods

Adult, male Sprague-Dawley rats underwent craniotomy and midline fluid percussion injury (FPI) (moderate severity; 1.8-2

SUBMITTER: Thomas TC 

PROVIDER: S-EPMC5491365 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature