The AURORA pilot study for molecular screening of patients with advanced breast cancer-a study of the breast international group.

ABSTRACT: Several studies have demonstrated the feasibility of molecular screening of tumour samples for matching patients with cancer to targeted therapies. However, most of them have been carried out at institutional or national level. Herein, we report on the pilot phase of AURORA (NCT02102165), a European multinational collaborative molecular screening initiative for advanced breast cancer patients. Forty-one patients were prospectively enroled at four participating centres across Europe. Metastatic tumours were biopsied and profiled using an Ion Torrent sequencing platform at a central facility. Sequencing results were obtained for 63% of the patients in real-time with variable turnaround time stemming from delays between patient consent and biopsy. At least one clinically actionable mutation w

SUBMITTER: Maetens M 

PROVIDER: S-EPMC5491498 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature