Retinal oxygen extraction in individuals with type 1 diabetes with no or mild diabetic retinopathy.

ABSTRACT:

Aims/hypothesis

The aim of this study was to compare retinal oxygen extraction in individuals with diabetes with no or mild non-proliferative diabetic retinopathy and healthy age- and sex-matched volunteers.

Methods

A total of 24 participants with type 1 diabetes and 24 healthy age- and sex-matched volunteers were included in this cross-sectional study. Retinal oxygen extraction was measured by combining total retinal blood flow measurements using a custom-built bi-directional Doppler optical coherence tomography system with measurements of oxygen saturation using spectroscopic reflectometry. Based on previously published mathematical modelling, the oxygen content in retinal vessels and total retinal oxygen extraction were calculated.

Results

Total retinal blood flow

SUBMITTER: Fondi K 

PROVIDER: S-EPMC5491565 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature