Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression.

ABSTRACT:

Introduction

Genomic and transcriptomic alterations affecting key cellular processes such us cell proliferation, differentiation and genomic stability are considered crucial for the development and progression of cancer. Most invasive breast carcinomas are known to derive from precursor in situ lesions. It is proposed that major global expression abnormalities occur in the transition from normal to premalignant stages and further progression to invasive stages. Serial analysis of gene expression (SAGE) was employed to generate a comprehensive global gene expression profile of the major changes occurring during breast cancer malignant evolution.

Methods

In the present study we combined various normal and tumor SAGE libraries available in the public domain with sets of breast

SUBMITTER: Abba MC 

PROVIDER: S-EPMC549167 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature