Recall T cell responses to bluetongue virus produce a narrowing of the T cell repertoire.

ABSTRACT: In most viral infections, recall T cell responses are critical for protection. The magnitude of these secondary responses can also affect the CD8 and CD4 epitope repertoire diversity. Bluetongue virus (BTV) infection in sheep elicits a T cell response that contributes to viremia control and could be relevant for cross-protection between BTV serotypes. Here, we characterized CD4⁺ and CD8⁺ T cell responses during primary and recall responses. During primary immune responses, both CD4⁺ and CD8⁺ T cell populations expanded by 14 days post-infection (dpi). CD4⁺ T cell populations showed a lower peak of expansion and prolonged contraction phase compared to CD8⁺ T cell populations. Recall responses to BTV challenge led to BTV-speci

SUBMITTER: Rojas JM 

PROVIDER: S-EPMC5492282 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature