P1.04: Defining the Genetic Architecture of Lung Cancer Etiology

ABSTRACT:

Background

Lung cancer is considered an archetypical environmentally induced disease because of the high risk from exposure to tobacco smoke. However, family studies clearly identified familial aggregation, beyond effects from familial correlations in smoking behavior. Family studies and genome wide association studies have identified selected variants influencing lung cancer risk but have been underpowered to provide a more comprehensive assessment of genetic architecture.

Method

We conducted a genome-wide association analysis using the Oncoarray, a genotyping platform that comprises over 530,000 genetic markers and designed to query variation influencing cancer risk. Here, we present the largest genome-wide scan of lung cancer susceptibility, in European-descent populat

SUBMITTER: Amos C 

PROVIDER: S-EPMC5492378 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature