Modulating Oxidative Stress Relieves Stress-Induced Behavioral and Cognitive Impairments in Rats.

ABSTRACT:

Background

Persistent psychological stress often leads to anxiety disorders and depression. Benzodiazepines and selective serotonin reuptake inhibitors are popular treatment options but have limited efficacy, supporting the need for alternative treatment. Based on our recent preclinical work suggesting a causal link between neurobehavioral deficits and elevated oxidative stress, we hypothesized that interventions that mitigate oxidative stress can attenuate/overcome neurobehavioral deficits.

Methods

Here, we employed the rat social defeat model of psychological stress to determine whether increasing antioxidant levels using grape powder would prevent and/or reverse social defeat-induced behavioral and cognitive deficits. Furthermore, a hippocampal-derived HT22 cell culture m

SUBMITTER: Solanki N 

PROVIDER: S-EPMC5492781 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature