Biomarkers of Environmental Enteric Dysfunction Among Children in Rural Bangladesh.

ABSTRACT:

Objectives

Environmental enteric dysfunction (EED) may inhibit growth and development in low- and middle-income countries, but available assessment methodologies limit its study. In rural Bangladesh, we measured EED using the widely used lactulose mannitol ratio (L:M) test and a panel of intestinal and systemic health biomarkers to evaluate convergence among biomarkers and describe risk factors for EED.

Methods

In 539 18-month-old children finishing participation in a randomized food supplementation trial, serum, stool, and urine collected after lactulose and mannitol dosing were analyzed for biomarkers of intestinal absorption, inflammation, permeability and repair, and systemic inflammation. EED scores for each participant were developed using principal component analysis

SUBMITTER: Campbell RK 

PROVIDER: S-EPMC5492885 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature