Neurophysiological Effects of Bitopertin in Schizophrenia.

ABSTRACT:

Purpose/background

Deficits in N-methyl-D-aspartate receptor (NMDAR) function contribute to symptoms and cognitive dysfunction in schizophrenia and are associated with impaired generation of event-related potential measures including auditory mismatch negativity. Parallel studies of the NMDAR agonist D-serine have suggested that sensitivity of these measures to glutamate-based interventions is related to symptomatic and cognitive response. Bitopertin is a selective inhibitor of glycine transport. This study investigates effects of bitopertin on NMDAR-related event-related potential deficits in schizophrenia.

Methods/procedures

Patients with schizophrenia/schizoaffective disorder were treated with bitopertin (10 mg, n = 29), in a double-blind, parallel group investigation. Au

SUBMITTER: Kantrowitz JT 

PROVIDER: S-EPMC5492956 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature