Role of environmental stressors in determining the developmental outcome of neonatal anesthesia.

ABSTRACT:

Background

The majority of studies evaluating neurocognition in humans who had procedures under anesthesia early in life found long-term deficits even though the typical anesthesia duration normalized to the human life span is much shorter than that shown to induce developmental abnormalities in rodents. Therefore, we studied whether subsequent environmental stressors contribute to deficiencies programmed by a brief neonatal etomidate exposure.

Methods

Postnatal days (P) 4, 5, or 6, Sprague-Dawley rats, pretreated with vehicle or the Na⁺-K⁺-2Cl^- (NKCC1) inhibitor, bumetanide, received two injections of etomidate resulting in anesthesia for 2h. To simulate stress after anesthesia, the animals were exposed to a single maternal separation for 3h

SUBMITTER: Ju LS 

PROVIDER: S-EPMC5492971 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature