Ontology highlight
ABSTRACT:
SUBMITTER: Farshidfar F
PROVIDER: S-EPMC5493145 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cell reports 20170301 11
Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. We identified an IDH mutant-enriched subtype with distinct molecular features including low expression of chromatin modifiers, elevated expre ...[more]