Assessing agreement between preclinical magnetic resonance imaging and histology: An evaluation of their image qualities and quantitative results.

ABSTRACT: One consequence of demographic change is the increasing demand for biocompatible materials for use in implants and prostheses. This is accompanied by a growing number of experimental animals because the interactions between new biomaterials and its host tissue have to be investigated. To evaluate novel materials and engineered tissues the use of non-destructive imaging modalities have been identified as a strategic priority. This provides the opportunity for studying interactions repeatedly with individual animals, along with the advantages of reduced biological variability and decreased number of laboratory animals. However, histological techniques are still the golden standard in preclinical biomaterial research. The present article demonstrates a detailed method comparison between histo

SUBMITTER: Elschner C 

PROVIDER: S-EPMC5493293 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature