Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer.

ABSTRACT:

Background

Carotenoids are a class of nutrients with antioxidant properties that have been purported to protect against cancer. However, the reported associations between carotenoids and prostate cancer have been heterogeneous and lacking data on interactions with nucleotide sequence variations and genomic biomarkers.

Objective

To examine the associations between carotenoid levels and the risk of high-grade prostate cancer, also considering antioxidant-related genes and tumor instability.

Methods

We measured plasma levels of carotenoids and genotyped 20 single nucleotide polymorphisms (SNP) in SOD1, SOD2, SOD3, XRCC1, and OGG1 among 559 men with non-metastatic prostate cancer undergoing radical prostatectomy. We performed copy number analysis in a subset of these men

SUBMITTER: Nordstrom T 

PROVIDER: S-EPMC5493324 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature