Gene expression allelic imbalance in ovine brown adipose tissue impacts energy homeostasis.

ABSTRACT: Heritable trait variation within a population of organisms is largely governed by DNA variations that impact gene transcription and protein function. Identifying genetic variants that affect complex functional traits is a primary aim of population genetics studies, especially in the context of human disease and agricultural production traits. The identification of alleles directly altering mRNA expression and thereby biological function is challenging due to difficulty in isolating direct effects of cis-acting genetic variations from indirect trans-acting genetic effects. Allele specific gene expression or allelic imbalance in gene expression (AI) occurring at heterozygous loci provides an opportunity to identify genes directly impacted by cis-acting genetic variants as indirect trans-acti

SUBMITTER: Ghazanfar S 

PROVIDER: S-EPMC5493397 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature