Angiotensin-converting enzyme affects the presentation of MHC class II antigens.

ABSTRACT: Antigen processing and presentation through the MHC class II pathway is critical for activating T helper cells. Angiotensin-converting enzyme (ACE) is a carboxyl peptidase expressed by antigen-presenting cells. By analysis of ACE null (knockout), wild-type, and ACE-overexpressing (ACE10) mice and the antigen-presenting cells derived from these mice, we found that ACE has a physiological role in the processing of peptides for MHC class II presentation. The efficiency of presenting MHC class II epitopes from ovalbumin (OVA) and hen egg lysosome is markedly affected by cellular ACE levels. Mice overexpressing ACE in myeloid cells have a much more vigorous CD4⁺ T-cell and antibody response when immunized with OVA. ACE is present in the endosomal pathway where MHC class II peptide pr

SUBMITTER: Zhao T 

PROVIDER: S-EPMC5493495 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature