Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: clues to the development of multiple sclerosis.

ABSTRACT: Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells from n=18 treatment-naive individuals with recently diagnosed CIS (<120 days) for disturbances in the phenotype of T regulatory (Treg), follicular T regulatory (Tfr), T helper (Th), follicular T helper (Tfh) and B cells. Relative to healthy controls (n=19), CIS was associated with lower proportions of suppressive CD45RA⁺FoxP3^lo Treg and Tfr cells and greater proportions of non-suppressive CD45RA^-FoxP3^lo and Th17-like Treg and Tfr. Lower Helios

SUBMITTER: Jones AP 

PROVIDER: S-EPMC5493587 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature