Controversies in Thrombolysis.

ABSTRACT:

Purpose of review

The purpose of the review is to examine recent evidence on the effects of intravenous thrombolysis and identify the remaining uncertainties.

Recent findings

We review the results of two large trials (the third International Stroke Trial (IST-3) and The Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)) and the publications from the individual patient data analyses of the trials of alteplase conducted by the Stroke Thrombolysis Trialists Collaboration. Despite about a 2% risk of fatal intracerebral haemorrhage, on average, adult patients of all ages treated with 0.9 mg/kg alteplase within 4.5 h will have better long-term functional outcome. The use of a lower dose of alteplase (0.6 mg/kg) is associated with a lower risk of haemorrhag

SUBMITTER: Sandercock PAG 

PROVIDER: S-EPMC5493717 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature