Glyceollins trigger anti-proliferative effects through estradiol-dependent and independent pathways in breast cancer cells.

ABSTRACT:

Background

Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract. In addition to estradiol (E2), a natural hormone, numerous compounds are able to bind ERs and modulate their activities. Among these compounds, phytoestrogens such as isoflavones, which are found in plants, are promising therapeutics for several pathologies. Glyceollins are second metabolites of isoflavones that are mainly produced in soybean in response to an elicitor. They have potentially therapeutic actions in breast cancer by reducing the proliferation of cancer cells. However, the molecular mechanisms driving these effects remain elusive.

Methods

First

SUBMITTER: Lecomte S 

PROVIDER: S-EPMC5493871 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature