A new genome-scale metabolic model of Corynebacterium glutamicum and its application.

ABSTRACT:

Background

Corynebacterium glutamicum is an important platform organism for industrial biotechnology to produce amino acids, organic acids, bioplastic monomers, and biofuels. The metabolic flexibility, broad substrate spectrum, and fermentative robustness of C. glutamicum make this organism an ideal cell factory to manufacture desired products. With increases in gene function, transport system, and metabolic profile information under certain conditions, developing a comprehensive genome-scale metabolic model (GEM) of C. glutamicum ATCC13032 is desired to improve prediction accuracy, elucidate cellular metabolism, and guide metabolic engineering.

Results

Here, we constructed a new GEM for ATCC13032, iCW773, consisting of 773 genes, 950 metabolites,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5493880 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature