Inhibition versus facilitation of contralesional motor cortices in stroke: Deriving a model to tailor brain stimulation.

ABSTRACT:

Objective

The standard approach to brain stimulation in stroke is based on the premise that ipsilesional M1 (iM1) is important for motor function of the paretic upper limb, while contralesional cortices compete with iM1. Therefore, the approach typically advocates facilitating iM1 and/or inhibiting contralesional M1 (cM1). But, this approach fails to elicit much improvement in severely affected patients, who on account of extensive damage to ipsilesional pathways, cannot rely on iM1. These patients are believed to instead rely on the undamaged cortices, especially the contralesional dorsal premotor cortex (cPMd), for support of function of the paretic limb. Here, we tested for the first time whether facilitation of cPMd could improve paretic limb function in severely affected patie

SUBMITTER: Sankarasubramanian V 

PROVIDER: S-EPMC5493996 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature