Race is associated with differences in airway inflammation in patients with asthma.

ABSTRACT:

Background

African American subjects have a greater burden from asthma compared with white subjects. Whether the pattern of airway inflammation differs between African American and white subjects is unclear.

Objective

We sought to compare sputum airway inflammatory phenotypes of African American and white subjects treated or not with inhaled corticosteroids (ICSs; ICS+ and ICS-, respectively).

Methods

We performed a secondary analysis of self-identified African American and white subjects with asthma enrolled in clinical trials conducted by the National Heart, Lung, and Blood Institute-sponsored Asthma Clinical Research Network and AsthmaNet. Demographics, clinical characteristics, and sputum cytology after sputum induction were examined. We used a sputum eosinophil 2

SUBMITTER: Nyenhuis SM 

PROVIDER: S-EPMC5494010 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature