IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis.

ABSTRACT:

Background

Generalized pustular psoriasis (GPP) is a rare, debilitating, and often life-threatening inflammatory disease characterized by episodic infiltration of neutrophils into the skin, pustule development, and systemic inflammation, which can manifest in the presence or absence of chronic plaque psoriasis (PV). Current treatments are unsatisfactory and warrant a better understanding of GPP pathogenesis.

Objective

We sought to understand better the disease mechanism of GPP to allow improved targeted therapies.

Methods

We performed a gene expression study on formalin-fixed paraffin-embedded GPP (n = 28) and PV (n = 12) lesional biopsies and healthy control (n = 20) skin. Differential gene expression was analyzed using gene ontology and enrichment analysis. Gene exp

SUBMITTER: Johnston A 

PROVIDER: S-EPMC5494022 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature