A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain.

ABSTRACT:

Background

Acute and chronic orofacial pain can significantly impact overall health and functioning. Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated. Little is known, however, regarding the specific genes contributing to fear of pain.

Methods

A genome-wide association study (GWAS; N = 990) was performed to identify plausible genes that may predispose individuals to various levels of fear of pain. The total score and three subscales (fear of minor, severe, and medical/dental pain) of the Fear of Pain Questionnaire-9 (FPQ-9) were modeled in a variance components modeling framework to test for genetic association with 8.5 M genetic vari

SUBMITTER: Randall CL 

PROVIDER: S-EPMC5494109 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature