Fluoride resistance capacity in mammalian cells involves complex global gene expression changes.

ABSTRACT: Fluorine is a bone-seeking element ubiquitously present in the environment and widely used in many oral hygiene products. In humans, excessive intake of fluoride may cause dental and skeletal fluorosis. However, endemic fluorosis does not appear to develop in a proportion of individuals exposed to the same levels of fluoride. The mechanisms by which mammalian cells resist fluoride are still unclear. In this study, we developed strains of mouse L-929 cells resistant to different levels of fluoride. High-throughput RNA-sequencing analyses of the fluoride-resistant L-929 cells indicated that massive changes in global gene expression occurred, compared with the wild-type L-929 cells. The main biological processes and functions changed were associated with the extracellular region and matrix, r

SUBMITTER: Ran S 

PROVIDER: S-EPMC5494298 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature