Functional remodeling of subtype-specific markers surrounding implanted neuroprostheses.

ABSTRACT: Microelectrode arrays implanted in the brain are increasingly used for the research and treatment of intractable neurological disease. However, local neuronal loss and glial encapsulation are known to interfere with effective integration and communication between implanted devices and brain tissue, where these observations are typically based on assessments of broad neuronal and astroglial markers. However, both neurons and astrocytes comprise heterogeneous cellular populations that can be further divided into subclasses based on unique functional and morphological characteristics. In this study, we investigated whether or not device insertion causes alterations in specific subtypes of these cells. We assessed the expression of both excitatory and inhibitory markers of neurotransmission (v

SUBMITTER: Salatino JW 

PROVIDER: S-EPMC5494361 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature