Effects of dobutamine on intestinal microvascular blood flow heterogeneity and O₂ extraction during septic shock.

ABSTRACT: Derangements of microvascular blood flow distribution might contribute to disturbing O₂ extraction by peripheral tissues. We evaluated the dynamic relationships between the mesenteric O₂ extraction ratio ([Formula: see text]) and the heterogeneity of microvascular blood flow at the gut and sublingual mucosa during the development and resuscitation of septic shock in a swine model of fecal peritonitis. Jejunal-villi and sublingual microcirculation were evaluated using a portable intravital-microscopy technique. Simultaneously, we obtained arterial, mixed-venous, and mesenteric blood gases, and jejunal-tonometric measurements. During resuscitation, pigs were randomly allocated to a fixed dose of dobutamine (5 µg·kg^-1·min^-1) or placebo while three s

SUBMITTER: Ospina-Tascon GA 

PROVIDER: S-EPMC5494430 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature