A <i>Pseudomonas aeruginosa</i> TIR effector mediates immune evasion by targeting UBAP1 and TLR adaptors.

ABSTRACT: Bacterial pathogens often subvert the innate immune system to establish a successful infection. The direct inhibition of downstream components of innate immune pathways is particularly well documented but how bacteria interfere with receptor proximal events is far less well understood. Here, we describe a Toll/interleukin 1 receptor (TIR) domain-containing protein (PumA) of the multi-drug resistant Pseudomonas aeruginosa PA7 strain. We found that PumA is essential for virulence and inhibits NF-κB, a property transferable to non-PumA strain PA14, suggesting no additional factors are needed for PumA function. The TIR domain is able to interact with the Toll-like receptor (TLR) adaptors TIRAP and MyD88, as well as the ubiquitin-associated protein 1 (UBAP1), a component of the endosomal

SUBMITTER: Imbert PR 

PROVIDER: S-EPMC5494471 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature