TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

ABSTRACT: Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such as Alzheimer's disease and frontotemporal lobar degeneration. In the brain, TREM2 is predominantly expressed in microglia. Several disease-associated TREM2 variants result in a loss of function by reducing microglial phagocytosis, impairing lipid sensing, preventing binding of lipoproteins and affecting shielding of amyloid plaques. We here investigate the consequences of TREM2 loss of function on the microglia transcriptome. Among the differentially expressed messenger RNAs in wild-type and Trem2^-/- microglia, gene clusters are identified which represent gene functions in chemotaxis, migration and mobility. Functional ana

SUBMITTER: Mazaheri F 

PROVIDER: S-EPMC5494532 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature