Chiral tether-mediated stabilization and helix-sense control of complementary metallo-double helices.

ABSTRACT: A series of novel Pt^II-linked double helices were prepared by inter- or intrastrand ligand-exchange reactions of the complementary duplexes composed of chiral or achiral amidine dimer and achiral carboxylic acid dimer strands joined by trans-Pt^II-acetylide complexes with PPh₃ ligands using chiral and achiral chelating diphosphines. The structure and stability of the Pt^II-linked double helices were highly dependent on the diphosphine structures. An interstrand ligand exchange took place with chiral and achiral 1,3-diphosphine-based ligands, resulting in trans-Pt^II-bridged double helices, whose helical structures were quite stable even in dimethyl sulfoxide (DMSO) due to the interstrand cross-link, whereas a 1,2-diphosphine

SUBMITTER: Horie M 

PROVIDER: S-EPMC5494540 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature