Overexpression of the transmembrane protein BST-2 induces Akt and Erk phosphorylation in bladder cancer.

ABSTRACT: Bladder cancer, the majority of which is urothelial carcinoma (UC), is a common malignancy worldwide. Genes encoding transmembrane/secretory proteins expressed specifically in certain cancers may be ideal biomarkers for cancer diagnosis and may represent therapeutic targets. In the present study, the expression and function of the bone marrow stromal cell antigen 2 (BST2) gene was analyzed in UC. Reverse transcription-quantitative polymerase chain reaction demonstrated that expression of BST2 in normal tissue samples was the highest in liver tissue. However, expression of BST2 in UC tissue samples was higher than in normal liver. Immunohistochemical analysis revealed weak or no staining of BST-2 in non-neoplastic mucosa, whereas UC tissue exhibited stronger and more ex

SUBMITTER: Shigematsu Y 

PROVIDER: S-EPMC5494661 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature