Impact of RASSF1A gene methylation on the metastatic axillary nodal status in breast cancer patients.

ABSTRACT: Hypermethylation of CpG islands is a hallmark of cancer and occurs at an early stage in breast tumorigenesis. To gain insight into the epigenetic switches that may promote and/or contribute to the initial neoplastic events during breast carcinogenesis, the present study focused on the DNA methylation profile of invasive breast carcinoma. The aim of the study was to evaluate the prognostic significance of Ras association domain family 1 isoform A (RASSF1A) promoter methylation status in operable breast cancer, and to analyze the utility of this biomarker regarding its association with metastatic and nonmetastatic axillary nodal status. For this purpose, formalin-fixed, paraffin-embedded tissue specimens from 116 breast cancer patients with known axillary nodal status were subjected t

SUBMITTER: Jezkova E 

PROVIDER: S-EPMC5494671 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature