The footprint of the ageing stroma in older patients with breast cancer.

ABSTRACT:

Background

Tumours are not only composed of malignant cells but also consist of a stromal micro-environment, which has been shown to influence cancer cell behaviour. Because the ageing process induces accumulation of senescent cells in the body, this micro-environment is thought to be different in cancers occurring in old patients compared with younger patients. More specifically, senescence-related fibroblastic features, such as the senescence-associated secretory profile (SASP) and the induction of autophagy, are suspected to stimulate tumour growth and progression.

Methods

We compared gene expression profiles in stromal fields of breast carcinomas by performing laser capture microdissection of the cancer-associated stroma from eight old (aged ≥80 years at diagnosis) and n

SUBMITTER: Brouwers B 

PROVIDER: S-EPMC5494807 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature