Altered protein levels in the isolated extracellular matrix of failing human hearts with dilated cardiomyopathy.

ABSTRACT: Dilated cardiomyopathy (DCM) is associated with extensive pathological cardiac remodeling and involves numerous changes in the protein expression profile of the extracellular matrix of the heart. We obtained seven human, end-stage, failing hearts with DCM (DCM-failing) and nine human, nonfailing donor hearts and compared their extracellular matrix protein profiles. We first showed that the DCM-failing hearts had indeed undergone extensive remodeling of the left ventricle myocardium relative to nonfailing hearts. We then isolated the extracellular matrix from a subset of these hearts and performed a proteomic analysis on the isolated matrices. We found that the levels of 26 structural proteins were altered in the DCM-failing isolated cardiac extracellular matrix compared to nonfailing isola

SUBMITTER: DeAguero JL 

PROVIDER: S-EPMC5494967 | biostudies-literature | 2017 Jan - Feb

REPOSITORIES: biostudies-literature