Inhibiting the BfrB:Bfd interaction in Pseudomonas aeruginosa causes irreversible iron accumulation in bacterioferritin and iron deficiency in the bacterial cytosol.

ABSTRACT: Iron is an essential nutrient for bacteria but the reactivity of Fe²⁺ and the insolubility of Fe³⁺ present significant challenges to bacterial cells. Iron storage proteins contribute to ameliorating these challenges by oxidizing Fe²⁺ using O₂ and H₂O₂ as electron acceptors, and by compartmentalizing Fe³⁺. Two types of iron-storage proteins coexist in bacteria, the ferritins (Ftn) and the heme-containing bacterioferritins (Bfr), but the reasons for their coexistence are largely unknown. P. aeruginosa cells harbor two iron storage proteins (FtnA and BfrB), but nothing is known about their relative contributions to iron homeostasis. Prior studies in vitro have shown that iron mobilization from BfrB requires specific

SUBMITTER: Eshelman K 

PROVIDER: S-EPMC5494978 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature