Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.

ABSTRACT: Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic VRE infections and patient-to-patient transmission. Although obligate anaerobic commensal bacteria have been associated with colonization resistance to VRE, the specific bacterial species involved remain undefined. Herein, we demonstrate that a precisely defined consortium of commensal bacteria containing the Clostridium cluster XIVa species Blautia producta and Clostridium bolteae restores colonization resistance against VRE and clears VRE from the intestines of mice. While

SUBMITTER: Caballero S 

PROVIDER: S-EPMC5494988 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature