PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.

ABSTRACT: Developmental and lineage plasticity have been observed in numerous malignancies and have been correlated with tumor progression and drug resistance. However, little is known about the molecular mechanisms that enable such plasticity to occur. Here, we describe the function of the plant homeodomain finger protein 6 (PHF6) in leukemia and define its role in regulating chromatin accessibility to lineage-specific transcription factors. We show that loss of Phf6 in B-cell leukemia results in systematic changes in gene expression via alteration of the chromatin landscape at the transcriptional start sites of B-cell- and T-cell-specific factors. Additionally, Phf6^KO cells show significant down-regulation of genes involved in the development and function of normal B cells

SUBMITTER: Soto-Feliciano YM 

PROVIDER: S-EPMC5495126 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature