Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men.

ABSTRACT:

Background

The Puerto Rican (PR) population is a racially admixed population that has a high prostate cancer (PCa) mortality rate. We hypothesized in this pilot study that West African Ancestry (WAA) was associated with PCa in this heterogeneous (PR) population.

Methods

A case/case and case/control study was performed. Controls, 207 African American (AA) and 133 PR were defined as men with no PCa, a serum PSA < 2.5 ng/mL and a negative rectal examination. Cases were patients with pathological specimens from radical prostatectomies (RP) (291 PR and 200 AA). DNA was extracted from whole blood of controls and from paraffin embedded normal seminal vesicle from the RPs. We assessed the association of PCa and aggressiveness with genetic ancestry using an ancestry informative marke

SUBMITTER: Irizarry-Ramirez M 

PROVIDER: S-EPMC5495141 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature