Attenuated neural response to emotional cues in cocaine-dependence: a preliminary analysis of gender differences.

ABSTRACT:

Background

Cocaine users often report a loss of arousal for nondrug-related stimuli, which may contribute to their response to drug-related rewards. However, little is known about users' neural reactivity to emotional nondrug-related stimuli and the potential influence of gender.

Objectives

Test the hypotheses that cocaine-dependent individuals have an attenuated neural response to arousing stimuli relative to controls and that this difference is amplified in women.

Methods

The brain response to typically arousing positive and negative images as well as neutral images from the International Affective Picture System was measured in 40 individuals (20 non-treatment seeking cocaine-dependent and 20 age- and gender-matched control participants; 50% of whom were women). Im

SUBMITTER: Canterberry M 

PROVIDER: S-EPMC5495203 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature