Systemic complement activation in central serous chorioretinopathy.

ABSTRACT:

Purpose

A clear link between several variants in genes involved in the complement system and chronic central serous chorioretinopathy (CSC) has been described. In age-related macular degeneration, a disease that shows clinical features that overlap with CSC, both genetic risk factors and systemic activation of the complement system have previously been found. In this case-control study, we assessed whether there is evidence of either systemic activation or inhibition of the complement system in patients with chronic CSC.

Methods

A prospective case-control study of 76 typical chronic CSC patients and 29 controls without ophthalmological history was conducted. Complement activity assays (classical, alternative, and mannose-binding lectin pathway), complement factors 3, 4, 4A,

SUBMITTER: van Dijk EHC 

PROVIDER: S-EPMC5495432 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature