Body Composition in Adolescents During Treatment With Selective Serotonin Reuptake Inhibitors.

ABSTRACT: To examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) to changes in body composition in older adolescents. Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Body Mass Index (BMI) was measured every 4 months. Every 8 months, a whole-body dual-energy radiograph absorptiometry scan was obtained to determine lean BMI, fat mass index, and visceral fat mass. Linear mixed effects regression analysis examined associations between MDD, GAD, and SSRI use variables and body composition measures. Over 1.51 ± 0.76 years of follow-up, 264 participant

SUBMITTER: Calarge CA 

PROVIDER: S-EPMC5495528 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature