Pilot study of angiogenic response to yttrium-90 radioembolization with resin microspheres.

ABSTRACT:

Purpose

To investigate the impact of radioembolization with yttrium-90 resin microspheres on the regulation of angiogenesis through observation of serial changes in a spectrum of angiogenic markers and other cytokines after therapy.

Materials and methods

This prospective pilot study enrolled 22 patients with liver-dominant disease deriving from biopsy-proven hepatocellular carcinoma (HCC) (n = 7) or metastatic colorectal carcinoma (mCRC) (n = 15). Circulating angiogenic markers were measured from serum samples drawn at baseline and at time points after therapy ranging from 6 hours to 120 days. Using multiplex enzyme-linked immunosorbent assay, several classic angiogenesis factors (vascular endothelial growth factor [VEGF], angiopoietin-2 [Ang-2], basic fibroblast growth fact

SUBMITTER: Carpizo DR 

PROVIDER: S-EPMC5496007 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature