A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings.

ABSTRACT:

Background

Diffusion tensor imaging studies show reductions in fractional anisotropy (FA) in individuals with bipolar disorder and their unaffected siblings. However, the use of various analysis methods is an important source of between-study heterogeneity. Using tract-based spatial statistics, we previously demonstrated widespread FA reductions in patients and unaffected relatives. To better interpret the neuroanatomical pattern of this previous finding and to assess the influence of methodological heterogeneity, we here applied tractography to the same sample.

Methods

Diffusion-weighted images were acquired for 96 patients, 69 unaffected siblings and 56 controls. We applied TRACULA, an extension of a global probabilistic tractography algorithm, to automatically segment 18

SUBMITTER: Sprooten E 

PROVIDER: S-EPMC5496097 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature