Abnormal circadian oscillation of hippocampal MAPK activity and power spectrums in NF1 mutant mice.

ABSTRACT: Studies have implied that the circadian oscillation of mitogen-activated protein kinase (MAPK) signal pathways is crucial for hippocampus-dependent memory. NF1 mouse models (Nf1 heterozygous null mutants; Nf1 ^+/-) displayed enhanced MAPK activity in the hippocampus and resulted in memory deficits. We assumed a link between MAPK pathways and hippocampal rhythmic oscillations, which have never been explored in Nf1 ^+/- mice. We demonstrated that the level of extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation in Nf1 ^+/- mice were significantly higher at nighttime than at daytime. Moreover, the in vivo recording revealed that for the Nf1 ^+/- group, the power spectral density of theta rhythm significantly decreased and the firing r

SUBMITTER: Chen L 

PROVIDER: S-EPMC5496334 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature